mood incongruent psychotic features
COVID-19 is an emerging and rapidly evolving situation. Account name Save an appointment to archive E-mail citation Add to Collections Add to My Bibliography Your search saved Create a file for external dating management software Your RSS Feed Full text links Actions Share Page navigation Incongruent psychotic characteristics in bipolar disorder: family aggregation and suggestive linkage to 2p11-q14 and 13q21-33 Membership Incongruent psychotic characteristics in bipolar disorder: family aggregation and suggestive linkage to 2p11-q14 and 13q21-33 Authors Membership Summary Objective: Incongruent psychotic characteristics of bipolar disease can mean a more severe form of the disease and can represent phenotypic manifestations of susceptibility genes shared with schizophrenia. This study seeks to characterize clinical correlates, family aggregation and genetic linkages in subjects with these characteristics. Method: The topics of the National Institute of Mental Health (NIMH) Genetics Initiative Bipolar Disorder Collaborative cohort, which consists of 708 families recruited in 10 academic medical centers. Subjects with psychotic characteristics consistent with mood and mood were compared in clinical variables. The family aggregation was tested using a predictive model of widespread bands and estimation equations. A link analysis was performed throughout the genome that incorporates a covariate of incongruity of humor. Results: The psychotic characteristics incongruent with the moods were associated with a higher rate of hospitalization and attempted suicide. A taste with incongruity of humor predicted the incongruity of relatives with bipolar disorder I compared to all other subjects and compared to subjects with congruent psychosis of humor. The presence of psychotic characteristics incongruent with the mood increased the evidence to link the chromosomes 13q21-33 and 2p11-q14. These logarithms of probabilities ratio scores (ODL) and their increase in the base met empirical criteria of genome worldwide suggestive for significance. Conclusions: The psychotic characteristics incongruent with the mood showed evidence of a more severe course, family aggregation and suggestive link to two chromosomal regions previously involved in the susceptibility of main mental illness. Finding 13q21-33 supports previous evidence of bipolar disorder/skezophrenia overlap in this region, while finding 2p11-q14 is, to the authors' knowledge, the first to suggest that this region of link schizophrenia could also host a gene of susceptibility of bipolar disorder. Comment in Similar articles Cited by 32 articles Types of publication MeSH Terms Related information Grant support Link Out - more resources Total Text sourcesMedicalResearch MaterialsMiscellaneousNCBI Literacy resources National Library of Medicine
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